Centred at the Prince of Wales Hospital in Shatin, the University's teaching hospital, the Department is fully committed to delivery of high quality patient services throughout the New Territories East and Kowloon East clusters of the Hospital Authority, with whom it works closely. It is closely affiliated with the Alice Ho Miu Ling Nethersole Hospital in Tai Po, New Territories and the United Christian Hospital in Kwun Tong, Kowloon. Outreach outpatient clinics and day surgery are also based at the North District Hospital in Fanling, New Territories and Tseung Kwan O Hospital, Tseung Kwan O.

The Department takes care of the widest possible spectrum of disorders and diseases of the ear, nose, throat, head and neck. It provides both emergency and elective ENT, head & neck, audiology and speech therapy service to an expanding population, currently at over 2 million, in the New Territories East of Hong Kong. Operations performed range from day surgery to major procedures including cochlear implantation and head and neck tumour resections. Outpatient services include general ENT clinics as well as dedicated subspecialist clinics covering voice, allergy, dysphagia, chronic ear problems and paediatric airway problems. Private consultations are conducted by the Department's specialist staff.